Thomas Jefferson University · Microbiology & ImmunologyThe ImmunoLegacy Lab
Botond Z Igyarto · Philadelphia, Pennsylvania
Research Focus
Dr. Botond Z Igyarto's lab at Thomas Jefferson University focuses on understanding how mRNA-LNP vaccines impact our immune system, particularly through mechanisms known as trained immunity. The research investigates not only the immediate immune responses to these vaccines but also their potential long-term effects across generations. By using advanced techniques such as single-cell analysis and mouse models, the lab aims to shed light on how vaccination may alter genetic factors in immune cells and influence our ability to respond to infections.
mRNA vaccinetrained immunityinnate immune responsetransgenerational healthimmunologyimmune tolerancedendritic cellspathway analysismolecular biology
Research Aims
5AIM 01Investigate the genetic changes induced by mRNA-LNP vaccines and their heritability.
AIM 02Characterize the innate immune changes triggered by mRNA-LNP exposure.
AIM 03Examine the transition from trained immunity to innate immune tolerance.
AIM 04Dissect the interplay between innate and adaptive immune responses post-exposure.
AIM 05Explore the influence of adjuvants on trained immunity.
Skills the Lab Values
single-cell multiomicsspatial transcriptomicsmouse modelspathway analysisin vitro assaysadoptive cell transfergene targeting techniquescell culturePCRflow cytometry
Output against the department
Publications81bottom 27% of dept.357th of 486
this lab
most publishedleast published
Citations6.6kbottom 48% of dept.254th of 486
this lab
most citedleast cited
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