University of California-Irvine · BiologyXu Neurogenetics Lab
Xiangmin Xu · Irvine, California
Research Focus
Dr. Xiangmin Xu's lab focuses on understanding how aging and Alzheimer's disease (AD) affect brain circuits and cellular functions. They use advanced mouse models and cutting-edge techniques to investigate the molecular mechanisms that lead to cognitive deficits in AD. Through their work, the lab aims to create better diagnostic tools and treatment strategies for this debilitating condition.
Alzheimer's Diseaseneural circuitssingle-cell analysisRNA splicingproteogenomicsage-related cognitive declinetauopathiesgene manipulationcell-type specificityhippocampal mapping
Research Aims
5AIM 01Map neural circuits involved in aging and Alzheimer's disease in mouse models.
AIM 02Identify molecular mechanisms of protein misfolding in tauopathies.
AIM 03Characterize gene expression changes in specific brain cell types impacted by AD.
AIM 04Develop tools to manipulate and study vulnerable brain cells in Alzheimer's research.
AIM 05Generate cellular resolution connectome data that combines molecular and anatomical information.
Skills the Lab Values
single-cell transcriptomicsspatial transcriptomicsproteomicsRNA MERFISHgenetic mouse modelsAAV-based genetic manipulationimmunofluorescence stainingmass spectrometryneural circuit mappingbio-orthogonal labeling
Output against the department
Publications366top 14% of dept.140th of 1,033
this lab
most publishedleast published
Citations11ktop 35% of dept.362nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.