AECAlbert Einstein College of Medicine · Biochemistry
Lai Lab
Jonathan R. Lai · Bronx, New York
Research Focus
Dr. Jonathan R. Lai's lab at Albert Einstein College of Medicine focuses on developing immunotherapies using human antibodies to combat alphavirus infections, such as Chikungunya and Mayaro viruses. The lab studies how these viruses cause diseases like arthritis and seeks to create effective antibody combinations to enhance protection against these viral infections. Their research could lead to new therapeutic options for patients suffering from alphavirus-related illnesses.
alphavirusChikungunya virusantibodiesimmunotherapyarthritisviral escape studiesantibody cocktailshuman monoclonal antibodiestherapeutic development
Research Aims
5AIM 01Engineer antibodies to improve their therapeutic properties
AIM 02Define viral escape mechanisms to enhance treatment strategies
AIM 03Test combinations of antibodies for synergistic effects in mouse models
AIM 04Evaluate pharmacokinetics and efficacy in non-human primate models
AIM 05Develop proof-of-concept therapies targeting broad alphavirus infections
Skills the Lab Values
cell sortingantibody engineeringanimal modelspharmacokinetic studiesviral neutralization assaysin vitro studiesmAb cocktail formulationdata analysisimmunological assays
Output against the department
Publications134bottom 38% of dept.248th of 402
this lab
most publishedleast published
Citations6.0kbottom 34% of dept.266th of 402
this lab
most citedleast cited
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