Icahn School of Medicine at Mount Sinai · NeuroscienceYang Neurogenetics Lab
Nan Yang · New York, New York
Research Focus
Dr. Nan Yang's research lab focuses on understanding the genetic factors that contribute to neuropsychiatric disorders such as schizophrenia and autism. By studying non-coding regions of the human genome, which are often overlooked, the lab aims to uncover how genetic variants affect neuronal function and contribute to disease risk. The goal is to develop new biological hypotheses that could lead to innovative therapeutic strategies for these complex conditions.
neuropsychiatric disordersnon-coding variantsgenetic riskneuronal subtypesenhancersepigeneticsGWASHiChIP technologytranscription regulation
Research Aims
5AIM 01Characterize functional non-coding regulatory elements in neuronal types.
AIM 02Identify target genes affected by non-coding variants.
AIM 03Investigate the impact of genetic variants on enhancer activity in neurons.
AIM 04Map enhancer-promoter interactions in active and resting states.
AIM 05Develop testable hypotheses for the role of non-coding regions in disease.
Skills the Lab Values
pluripotent stem cell cultureHiChIPgene expression analysisenhancer assaysCRISPRbioinformaticsdata analysisgenetic mappingcellular reprogramming
Output against the department
Publications167top 45% of dept.298th of 671
this lab
most publishedleast published
Citations4.1kbottom 31% of dept.466th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.