University of Virginia-Main Campus · Microbiology & ImmunologyAgaisse Lab
Herve F Agaisse · Charlottesville, Virginia
Research Focus
Dr. Herve Agaisse's lab at the University of Virginia focuses on understanding the illness caused by the bacteria Shigella flexneri, which leads to severe diarrhea and intestinal damage. They study how the bacteria invade the intestinal cells and interact with the immune system, using infant rabbits as a model to better represent human disease. Through their research, they aim to identify host factors that play crucial roles in shigellosis, ultimately contributing to new treatment strategies for this widespread public health issue.
Shigella flexnerishigellosisintestinal infectionimmune responseinfant rabbits
Research Aims
3AIM 01Investigate the route of intestinal cell infection by S. flexneri in the colon.
AIM 02Clarify the role of neutrophils in shigellosis and their effects on colonic tissue.
AIM 03Determine the mechanisms of S. flexneri interaction with macrophages and dendritic cells.
Skills the Lab Values
animal modelscell cultureflow cytometryin vivo imagingimmunohistochemistry
Output against the department
Publications94bottom 32% of dept.329th of 486
this lab
most publishedleast published
Citations6.1kbottom 45% of dept.268th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.