Iowa State University · PhysiologyAcute Lung Inflammation Lab
Yutong Zhao · Ames, Iowa
Research Focus
Dr. Yutong Zhao's lab at Ohio State University focuses on understanding the mechanisms of acute inflammatory diseases and idiopathic pulmonary fibrosis (IPF). The team investigates how specific proteins regulate cell metabolism, inflammation, and fibrosis in the lungs. By studying these processes, they aim to identify new therapeutic strategies to treat conditions like sepsis and lung injuries.
inflammationacute lung injuryidiopathic pulmonary fibrosisBMPRIImicrovascular dysfunctionUSP30Nedd4LmiRNAcell metabolism
Research Aims
3AIM 01Identify if inhibiting USP30 can improve endothelial function during acute lung injury.
AIM 02Investigate how USP30 affects miRNA biogenesis related to cell metabolism.
AIM 03Determine the role of Nedd4L in stabilizing BMPRII in lung fibrosis.
Skills the Lab Values
cell culturemouse modelsRNA sequencingWestern blotimmunofluorescencetransfection techniquesprotein purificationflow cytometrybiochemical assays