Yale University · BiochemistryHIV Biology and Maturation Unit
Yong Xiong · New Haven, Connecticut
Research Focus
The Xiong laboratory at Yale University focuses on understanding the life cycle of HIV-1, particularly how the virus matures and enters the nucleus of host cells. By using advanced imaging techniques like cryo-electron microscopy, the lab investigates the structural changes that occur during the maturation of the HIV-1 capsid and how this process can be inhibited by certain drugs. Their research aims to advance our understanding of HIV-1 biology and contribute to the development of new anti-HIV therapies.
HIV-1maturation pathwaysnuclear transportcryo-electron microscopycapsid inhibitorsDNA nanotechnologydrug developmentmolecular mechanismsbiochemistry
Research Aims
5AIM 01Determine the structural pathway of HIV-1 Gag assemblies during maturation in their native environment.
AIM 02Investigate how HIV-1 capsid cofactors and inhibitors influence virus maturation.
AIM 03Develop innovative in vitro platforms to study HIV-1 nuclear entry mechanisms using DNA nanotechnology.
AIM 04Define molecular interactions between HIV-1 capsids and nuclear pore components using biochemical methods.
AIM 05Validate findings through virologic experiments to enhance understanding of HIV-1 infection processes.
Skills the Lab Values
cryo-electron microscopyin vitro experimental designDNA nanotechnologycell cultureprotein biochemistryvirion analysisstructural biology techniquesfluorescence microscopybiochemical assays
Output against the department
Publications238top 32% of dept.127th of 402
this lab
most publishedleast published
Citations9.3kbottom 48% of dept.211th of 402
this lab
most citedleast cited
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