Johns Hopkins University · GeneticsMccallion Lab
Andrew S Mccallion · Baltimore, Maryland
Research Focus
Dr. Andrew S. Mccallion's lab at Johns Hopkins University focuses on understanding how genetic variations in noncoding DNA affect the risk and progression of Parkinson's disease (PD). They aim to investigate the regulatory changes in brain cells that contribute to PD by studying gene regulation and expression in dopamine neurons. Through advanced computational and experimental techniques, the lab seeks to uncover the mechanisms that link genetic factors to disease outcomes, which could inform future treatments and interventions.
Parkinson's diseasegene regulationnoncoding DNAregulatory variationdopaminergic neuronsmachine learningfunctional genomicsstem cellsdisease progressiongenome-wide association studies
Research Aims
3AIM 01Investigate the chromatin and transcriptional changes in dopamine neurons related to Parkinson's disease.
AIM 02Develop computational tools to analyze regulatory variations and their effects on gene expression.
AIM 03Test the functional consequences of disrupting key transcription factors in models of Parkinson's disease.
Skills the Lab Values
ATAC-seqChIP-seqbioinformaticsdata analysiscell culturehuman induced pluripotent stem cellsmachine learninggene expression profilingreporter assaysfunctional assays
Output against the department
Publications125bottom 39% of dept.158th of 259
this lab
most publishedleast published
Citations5.3kbottom 29% of dept.184th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.