University of Florida · GeneticsAlzheimer's Genetics and Neurodegeneration Lab
Lien Nguyen · Gainesville, Florida
Research Focus
The research lab led by Dr. Lien Nguyen at the University of Florida focuses on understanding the genetic factors that influence Alzheimer's disease (AD), particularly the role of specific repeat expansions in the CASP8 gene. Their work aims to link these genetic variations to the development of toxic protein aggregates in the brain, which may drive the progression of AD. By investigating these mechanisms, they hope to uncover new therapeutic strategies to combat this widespread and debilitating condition.
Alzheimer's diseaseCASP8repeat expansionspolyGR proteinsneurodegeneration
Research Aims
3AIM 01Investigate accumulation of repeat expansion products in Alzheimer's brains
AIM 02Examine molecular hallmarks of Alzheimer's in patient-derived organoids
AIM 03Assess the effects of blocking CASP8ADR1 expression on disease phenotypes.
Skills the Lab Values
RNA extractionPCRCRISPR/Cas technologycell cultureprotein aggregation analysisimmunohistochemistryhuman organoid modelinggenetic profilingbioinformaticswestern blot
Output against the department
Publications25bottom 3% of dept.251st of 259
this lab
most publishedleast published
Citations974bottom 4% of dept.248th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.