University of Maryland, Baltimore · Microbiology & ImmunologyBacterial Resistance Mechanisms Lab
Som Chatterjee · Baltimore, Maryland
Research Focus
Dr. Som Chatterjee's lab at the University of Maryland Baltimore focuses on understanding how certain bacterial proteins enable Staphylococcus aureus, particularly methicillin-resistant strains (MRSA), to resist common antibiotics called beta-lactams. The research explores a specific signaling pathway involving serine/threonine kinases that influence the bacteria's resistance mechanisms, aiming to identify new treatment options for these difficult infections. This work combines molecular biology techniques with genetic studies to uncover novel strategies for combating antibiotic resistance.
beta-lactam resistanceMRSAStaphylococcus aureuskinase signalingantibiotic resistance
Research Aims
3AIM 01Decipher how eSTK controls mecA expression in MRSA
AIM 02Identify mediators of non-classical beta-lactam resistance
AIM 03Investigate compensatory mechanisms in resistant strains
Skills the Lab Values
molecular cloninggenome sequencingbacterial culturingprotein purificationgene expression analysisphosphorylation assaysbiochemical assayscell survival assays
Output against the department
Publications41bottom 7% of dept.453rd of 486
this lab
most publishedleast published
Citations2.8kbottom 19% of dept.395th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.