University of Southern California · Microbiology & ImmunologyThe Resistance Research Lab
Myron Goodman · Los Angeles, California
Research Focus
Dr. Myron Goodman's lab focuses on understanding how certain bacteria develop resistance to antibiotics, which is a serious health issue worldwide. They study an enzyme called Rum DNA polymerase that causes mutations in bacteria, helping them to quickly become resistant to drugs. By exploring how these mutations occur, the lab aims to find ways to combat antibiotic resistance.
antibiotic resistanceDNA polymerasemutagenesisEscherichia coliVibrio choleraegenomic instabilitymolecular microscopyCryo-electron microscopyhigh-throughput sequencing
Research Aims
4AIM 01Investigate how Rum DNA polymerase contributes to rapid acquisition of antibiotic resistance in bacteria.
AIM 02Map areas of genomic instability associated with mutations induced by antibiotics and environmental stressors.
AIM 03Visualize the assembly of Rum polymerase into active mutasomal complexes using advanced microscopy.
AIM 04Determine high-resolution structures of activated Rum polymerase to identify potential drug targets.
Skills the Lab Values
PCRDNA sequencingTIRF-FRET microscopyCryo-electron microscopybacterial culturegenomic mappingmutational analysisprotein purificationfluorescence microscopy
Output against the department
Publications359top 11% of dept.55th of 486
this lab
most publishedleast published
Citations26ktop 13% of dept.64th of 486
this lab
most citedleast cited
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