Duke University · NeuroscienceHuang Neuroscience Lab
Z Josh Huang · Durham, North Carolina
Research Focus
Josh Huang's lab at Duke University focuses on developing innovative RNA-based technologies to analyze and manipulate brain cell types across different vertebrate species. Their research aims to improve our understanding of neural circuits and how they contribute to behaviors and cognitive functions. By creating scalable tools for targeted gene therapy and studying cell types in various animals, the lab hopes to advance neuroscience and address neuropsychiatric disorders, ultimately transforming our approach to brain research.
RNA editingcell type targetingneurosciencegene therapycomparative biologyneuropsychiatric diseasesneural circuitsspatial transcriptomicsRNA sensorsviral vectors
Research Aims
5AIM 01Develop RNA-programmable tools for cell type manipulation in the brain.
AIM 02Identify and catalog RNA sensors specific to various brain cell types.
AIM 03Validate the functionality of RNA sensors across vertebrate species.
AIM 04Establish a high-throughput screening platform for RNA sensors.
AIM 05Explore the application of these tools in gene therapy for neuropsychiatric diseases.
Skills the Lab Values
RNA sequencingcell culturemolecular cloningviral transductiongenetic editing using RNAspatial transcriptomicsbioinformatics data analysisanimal modelsimmunostainingin situ hybridization
Output against the department
Publications172top 44% of dept.293rd of 671
this lab
most publishedleast published
Citations28ktop 14% of dept.95th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.