Columbia University in the City of New York · BiologyTumor Microenvironment and Immune Dynamics Lab
Jellert Gaublomme · New York, New York
Research Focus
Dr. Jellert Gaublomme's lab at Columbia University focuses on understanding how cells in tumors interact with their environment and how these interactions influence cancer progression and treatment responses. By using innovative CRISPR techniques, the lab aims to map the complex cellular architecture within tumors and identify potential therapeutic targets that can help enhance the immune system's ability to fight cancer. This research is crucial for developing more effective treatments for liver cancer and other malignancies.
CRISPRtumor microenvironmentimmunosuppressiontherapeutic targetstranscriptomicsproteomicsin vivo screeningcellular interactionsHepatocellular carcinoma
Research Aims
5AIM 01Map cellular interactions in the tumor microenvironment.
AIM 02Understand signaling pathways that lead to immunosuppression.
AIM 03Identify genetic targets for therapeutic intervention in cancer.
AIM 04Develop in vivo CRISPR screening techniques to study tumors.
AIM 05Enhance immune system responses against tumors.
Skills the Lab Values
CRISPR screeningin situ imagingcell culturemouse modelstranscriptomic analysisproteomic analysisspatial mappingdata analysis in Rmultiplex imaging
Output against the department
Publications32bottom 4% of dept.988th of 1,033
this lab
most publishedleast published
Citations5.5kbottom 40% of dept.615th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.