The University of Texas Health Science Center at San Antonio · BiochemistryDNA Repair and Cancer Therapeutics Lab
Patrick Sung · San Antonio, Texas
Research Focus
Dr. Patrick Sung's lab studies the intricate mechanisms by which cells repair harmful DNA damage, specifically focusing on a critical repair process called homology-directed repair (HDR). By understanding how various proteins interact to facilitate or inhibit this process, the lab aims to uncover insights into cancer biology, particularly regarding how the failure of these repair pathways can lead to tumor development. Their research is aimed at developing new therapeutic strategies for treating cancers associated with defects in DNA repair processes.
DNA RepairHomology-directed RepairBRCA ProteinsGenome StabilityCancer Therapeutics
Research Aims
5AIM 01Investigate how proteins like RIF1 and Shieldin regulate DNA end resection.
AIM 02Elucidate the role of BRCA1-BARD1 in DNA repair mechanisms.
AIM 03Develop chemical inhibitors to study HDR processes.
AIM 04Understand the interplay between different DNA repair pathways in cancer.
AIM 05Identify biomarkers linked to cancer treatment responses.
Skills the Lab Values
Cell CultureBiochemical AssaysProtein PurificationDNA Manipulation TechniquesMicroscopy
Output against the department
Publications389top 13% of dept.51st of 402
this lab
most publishedleast published
Citations28ktop 12% of dept.50th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.