Duke University · ChemistryDerbyshire Malaria Lab
Emily R Derbyshire · Durham, North Carolina
Research Focus
Dr. Emily R. Derbyshire's lab at Duke University focuses on uncovering how malaria-causing parasites interact with their human hosts. They study specific proteins that the parasites hijack from human cells to survive and thrive, exploring potential new ways to target these interactions for drug development. The lab combines techniques in chemical biology and imaging to understand these complex relationships and ultimately advance treatment strategies against malaria.
Plasmodiummalariachemical biologyhost-parasite interactionheat shock proteinsaquaporin-3drug resistanceimaging techniquesbiochemical probes
Research Aims
5AIM 01Investigate the role of aquaporin-3 in Plasmodium infection using imaging techniques.
AIM 02Characterize the functions of heat shock proteins in the parasite's lifecycle.
AIM 03Develop chemical probes to study critical host proteins involved in malaria.
AIM 04Map host-parasite interactions to identify potential drug targets.
AIM 05Explore the dynamics of protein recruitment at the host-pathogen interface.
Skills the Lab Values
live-cell imagingchemical probe developmentimmuno-electron microscopyRNA sequencingbiochemical affinity assayscell cultureprotein-protein interaction studiesmicroscopymolecular dynamics modeling
Output against the department
Publications106bottom 22% of dept.169th of 216
this lab
most publishedleast published
Citations3.3kbottom 22% of dept.168th of 216
this lab
most citedleast cited
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