Washington University in St Louis · BiologyAmarasinghe Virology Lab
Gaya K. Amarasinghe · Saint Louis, Missouri
Research Focus
Dr. Gaya K. Amarasinghe's lab at Washington University focuses on understanding how certain viruses, specifically bunyaviruses and filoviruses, interact with their host cells to cause disease. This research aims to identify the key proteins and pathways involved in viral entry and pathogenesis, which could lead to the development of new therapeutics against these emerging infectious diseases. The lab combines techniques from biochemistry, virology, and molecular biology to explore these interactions in detail.
bunyavirusesfilovirusesviral pathogenesishost-virus interactiontherapeutic targets
Research Aims
5AIM 01Characterize the role of Lrp1 in the entry of multiple bunyaviruses.
AIM 02Define molecular mechanisms of filoviral-host interactions.
AIM 03Identify key pathogenic interactions that promote viral growth.
AIM 04Explore therapeutic targets for bunyavirus and filovirus infections.
AIM 05Develop new methods for studying virus-host dynamics in vitro and in vivo.
Skills the Lab Values
cell culturemolecular cloningWestern blottingbiochemical assaysin vitro viral infection modelsproteomicsanimal modelsgenomic screeningstructural biology techniquesmass spectrometry
Output against the department
Publications184top 36% of dept.367th of 1,033
this lab
most publishedleast published
Citations11ktop 34% of dept.356th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.