University of Rochester · PharmacologyCenter for Neurovascular Regulation
Scott Earley · Rochester, New York
Research Focus
Dr. Scott Earley's lab at the University of Rochester focuses on understanding how the brain regulates blood flow through a network of specialized sensors known as TRP channels. These channels play a critical role in maintaining healthy microcirculation by responding to changes in the brain’s environment. The lab uses advanced techniques, such as imaging and genetics, to explore how these sensors work, especially during conditions like aging and related cerebrovascular diseases.
TRP channelscerebral microvasculatureblood flow regulationvascular diseasesneurovascular coupling
Research Aims
5AIM 01Investigate how TRP channels sense and respond to stimuli in cerebral blood vessels.
AIM 02Determine the role of TRPM4 and TRPML1 channels in myogenic tone regulation.
AIM 03Explore how TRPA1 channels aid neurovascular coupling by detecting reactive oxygen species.
AIM 04Characterize new genetic mouse models for studying age-related cerebrovascular diseases.
AIM 05Examine the impact of aging on TRP channel function in the brain.
Skills the Lab Values
super-resolution microscopygenetic mouse modelsvascular smooth muscle cell cultureimmunohistochemistrydata analysis in MATLAB
Output against the department
Publications171bottom 47% of dept.245th of 462
this lab
most publishedleast published
Citations6.1kbottom 44% of dept.260th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.