University of North Carolina at Chapel Hill · PharmacologyAlzheimer's Drug Discovery Lab
Konstantin Popov · Chapel Hill, North Carolina
Research Focus
Dr. Konstantin Popov's lab at the University of North Carolina Chapel Hill focuses on developing new drug discovery methods to tackle Alzheimer's disease using artificial intelligence. The lab integrates computational techniques with experimental workflows to identify and optimize small-molecule drugs that can influence key proteins involved in the disease. By combining modern technology with traditional research methods, the lab aims to create effective therapies for neurodegenerative disorders.
Alzheimer's Diseasedrug discoveryartificial intelligenceneurodegenerative disordersphagocytosisexperimental workflowchemical probessmall-molecule modulatorsAI-assisted optimizationprotein targets
Research Aims
5AIM 01Develop AI-driven methods to design DNA-encoded libraries for Alzheimer's disease targets.
AIM 02Implement an experimental pipeline for hit discovery and validation of small-molecule modulators.
AIM 03Optimize promising drug leads using AI assistance in cellular models.
AIM 04Integrate AI methodologies with traditional drug discovery processes for enhanced results.
AIM 05Share validated AI-driven methodologies with the broader scientific community to improve drug discovery.
Skills the Lab Values
AI-driven computational methodschemical library designexperimental validationcell cultureanimal modelsdrug screeningbiochemical assaysmolecular dockingstep-by-step experimental workflowsdata analysis in pharmacology
Output against the department
Publications380top 17% of dept.77th of 462
this lab
most publishedleast published
Citations6.8kbottom 48% of dept.242nd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.