Northwestern University · BiologyUlcerative Colitis Research Lab
Ronen Sumagin · Evanston, Illinois
Research Focus
Dr. Ronen Sumagin's lab at Northwestern University studies ulcerative colitis, a chronic inflammatory bowel disease affecting many people. The lab focuses on understanding why certain biologic therapies, which are often expensive, work poorly for many patients. They investigate the role of specific types of immune cells called neutrophils in the gut and how these cells might be keeping treatment from being effective, aiming to find new ways to help patients respond better to their therapies.
ulcerative colitisbiologicsneutrophilsintestinal stem cellstreatment resistance
Research Aims
4AIM 01Profile neutrophils and T-cells in ulcerative colitis patients to identify gene and protein signatures linked to response to therapy.
AIM 02Investigate how intra-epithelial neutrophils affect treatment outcomes and injury resolution in murine colitis models.
AIM 03Define the molecular cues that retain neutrophils in the intra-epithelial space and relate this to therapeutic resistance.
AIM 04Identify targets for improving the response to biologic therapies in ulcerative colitis.
Skills the Lab Values
cell culturemurine modelsgene expression profilingimmunohistochemistrysingle-cell RNA sequencing
Output against the department
Publications119bottom 43% of dept.589th of 1,033
this lab
most publishedleast published
Citations4.4kbottom 34% of dept.680th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.