University of Utah · NeuroscienceThe Neuroprotective Initiative
Daniel R Scoles · Salt Lake City, Utah
Research Focus
Dr. Daniel R. Scoles' lab focuses on understanding how certain kinases, particularly PASK, regulate cell processes and contribute to neurodegenerative diseases like ALS and FTD. They investigate the roles of protein modifications and genetic interactions, aiming to develop new therapeutic strategies. The research combines genetic models and cell studies to pave the way for potential treatments.
ALSFTDPASKneurodegenerationautophagytherapeutic targetsprotein phosphorylationtransgenic miceiPSC neurons
Research Aims
3AIM 01Identify phosphorylated peptides of the ATXN2 protein using proteomics.
AIM 02Demonstrate genetic interactions that modify disease phenotypes in SCA2 and TDP-43 mouse models.
AIM 03Conduct proof-of-concept studies showing the effectiveness of targeting PASK for treatment.
Skills the Lab Values
PCRcell cultureRNA interferenceproteomicsWestern blottingmouse modelsmass spectrometrygene editingtranscriptome analysis
Output against the department
Publications95bottom 31% of dept.464th of 671
this lab
most publishedleast published
Citations2.8kbottom 18% of dept.547th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.