MCWMedical College of Wisconsin · Physiology
Salt Sensitivity Research Lab
Allen W Cowley · Milwaukee, Wisconsin
Research Focus
Dr. Allen W. Cowley's lab investigates how a high-salt diet influences kidney health and metabolic processes, especially in individuals who are sensitive to salt. They focus on understanding the differences between salt-sensitive and salt-resistant rat models to identify potential therapeutic targets for hypertension and kidney injury. This research is significant given the widespread prevalence of salt-sensitive hypertension and its implications for cardiovascular health.
hypertensionkidney diseasesalt sensitivitymetabolismoxidative stressmitochondriaaerobic glycolysisbioenergeticscomputational modelingrenal function
Research Aims
3AIM 01Investigate mitochondrial respiration and ATP production in renal cortical proximal tubules of salt-sensitive rats.
AIM 02Examine the failure of salt-sensitive rats to upregulate protective metabolic pathways leading to kidney injury.
AIM 03Develop mechanistic computational models to predict metabolic changes and identify therapeutic targets for salt-sensitive hypertension.
Skills the Lab Values
metabolomic analysistranscriptomic profilingATP measurementmouse modelscell cultureoxidative stress assaysgenetic engineeringcomputational modelingbiochemical pathway analysisdata analysis
Output against the department
Publications531top 5% of dept.14th of 286
this lab
most publishedleast published
Citations20ktop 14% of dept.41st of 286
this lab
most citedleast cited
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