Johns Hopkins University · EngineeringGray Lab
Jeffrey J Gray · Baltimore, Maryland
Research Focus
Dr. Jeffrey J. Gray's lab at Johns Hopkins University focuses on predicting how proteins interact with one another and how their structures can reveal important biological mechanisms. They develop computational tools to model these protein structures, which are crucial for understanding diseases and creating new therapies, particularly in areas like immunology and cancer. Their work also involves designing antibodies to target specific diseases and incorporates modeling carbohydrates that affect protein functions.
protein-protein interactionscomputational modelingantibody designglycosylationprotein docking
Research Aims
5AIM 01Predict the three-dimensional structures of protein complexes.
AIM 02Model antibody-antigen interactions for diagnostics and therapies.
AIM 03Develop tools for understanding glycan interactions in protein function.
AIM 04Create collaborative platforms for biomolecular structure prediction.
AIM 05Optimize protein engineering methods for therapeutic applications.
Skills the Lab Values
computational protein modelingprotein dockingantibody structure predictionsoftware development with Rosettaprotein design
Output against the department
Publications377top 20% of dept.55th of 278
this lab
most publishedleast published
Citations21ktop 17% of dept.47th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.