University of Pittsburgh-Pittsburgh Campus · Biomedical EngineeringCancer Immunotherapy and Immune Response Lab
Christopher J. Bakkenist · Pittsburgh, Pennsylvania
Research Focus
Dr. Christopher J. Bakkenist's lab focuses on understanding how certain cancer treatments can inadvertently affect the immune system. Specifically, they study how deoxyuridine, a byproduct of chemotherapy, impacts the way the body's immune system recognizes and responds to DNA contamination. This research aims to uncover mechanisms that may enhance the effectiveness of cancer therapies and improve patient outcomes.
deoxyuridineinnate immune responseDNA damagecancer immunotherapyATR inhibitors
Research Aims
3AIM 01Identify which pattern recognition receptors fail to detect DNA fragments with deoxyuridine
AIM 02Determine the effect of deoxyuridine on RNA transcription by innate immune receptors
AIM 03Explore how deoxyuridine contamination affects immune responses in cancer models treated with radiation.
Skills the Lab Values
DNA repair assaysmouse models of cancercell culture techniquesPCRimmunofluorescence microscopy
Output against the department
Publications142bottom 30% of dept.417th of 595
this lab
most publishedleast published
Citations8.9ktop 38% of dept.228th of 595
this lab
most citedleast cited
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