UMCUniversity of Massachusetts Chan Medical School · Biology
Allergy and Immune Response Lab
Gowthaman Uthaman · Worcester, Massachusetts
Research Focus
Dr. Gowthaman Uthaman's lab at the University of Massachusetts Medical School focuses on understanding how specific immune cells contribute to allergenic responses in the body. The research particularly investigates a novel type of T helper cell, called Tfh13 cells, which are vital in producing IgE antibodies responsible for dangerous allergic reactions. By studying these cells, the lab aims to discover new ways to prevent or treat severe allergies and anaphylaxis.
Tfh13 cellsIgE productionallergyanaphylaxisimmune response
Research Aims
3AIM 01Identify the mechanisms that drive Tfh13 cell differentiation during allergic sensitization.
AIM 02Investigate the role of non-conventional antigen presenting cells in Tfh13 cell development.
AIM 03Determine the impact of type II cytokines on the differentiation pathways of Tfh cells.
Skills the Lab Values
cell culturemouse modelsimmunological assaysflow cytometrycytokine analysis
Output against the department
Publications4bottom 1% of dept.1,026th of 1,033
this lab
most publishedleast published
Citations14bottom 1% of dept.1,024th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.