Duquesne University · ChemistryThe RNA Dynamics Lab
Jeffrey D Evanseck · Pittsburgh, Pennsylvania
Research Focus
Dr. Jeffrey D Evanseck's lab at Duquesne University focuses on understanding dynamic RNA structures involved in viral functions. By studying how different RNA complexes form and evolve, the lab aims to identify new targets for antiviral therapies against diseases like HIV-1 and SARS-CoV-2. The lab emphasizes training undergraduate students in both theoretical and experimental techniques to prepare them for careers in biomedical research.
RNA structuresviral dynamicsantiviral targetsHIV-1SARS-CoV-2drug resistanceoligonucleotidescomputational chemistrybiochemical processespathway modeling
Research Aims
3AIM 01Establish unbiased structures and dynamics for key RNA complexes involved in viral replication.
AIM 02Identify meta-stable states along RNA strand displacement pathways.
AIM 03Screen for RNA-binding molecules to target specific RNA intermediates.
Skills the Lab Values
RNA structure analysiscomputational modelingstrand displacement reactionsantiviral drug screeningdata analysismolecular dynamics simulationskinetic and thermodynamic assessmentsoligonucleotide designbiochemical assaysprotein chaperone studies
Output against the department
Publications125bottom 28% of dept.156th of 216
this lab
most publishedleast published
Citations18ktop 28% of dept.60th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.