Duke University · GeneticsThe Microbiome Nexus
John F Rawls · Durham, North Carolina
Research Focus
Dr. John F. Rawls' lab focuses on how gut microbes influence intestinal health and inflammation. By studying the interactions between the gut microbiota and intestinal cells, the lab aims to uncover mechanisms that contribute to conditions like inflammatory bowel disease. This research has the potential to inform new diagnostic and therapeutic strategies for treating intestinal infections and diseases.
intestinemicrobiotainflammationBacteroides vulgatusgene expressionhost-microbe interactiontranscription factorsenterovirusintestinal health
Research Aims
5AIM 01Investigate how microbiota influence intestinal epithelial gene regulation.
AIM 02Define the interactions between HNF4A and immune signaling in enterocytes.
AIM 03Characterize genetic diversity within Bacteroides vulgatus strains.
AIM 04Assess the relationship between Bacteroides vulgatus and host inflammatory responses.
AIM 05Explore the potential of microbiome-modifying treatments for inflammatory bowel diseases.
Skills the Lab Values
single-cell RNA sequencinggnotobiotic mice modelsproteomicscell culturegenetic manipulationDNA sequencingbioinformaticsmetabolomicsmass spectrometryimmunological assays
Output against the department
Publications314top 27% of dept.69th of 259
this lab
most publishedleast published
Citations22ktop 25% of dept.66th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.