Stanford University · BiologyAlzheimer's Research and Therapeutics Lab
Thomas J Montine · Stanford, California
Research Focus
Dr. Thomas J. Montine's lab at Stanford University focuses on understanding the molecular mechanisms behind Alzheimer's disease (AD) and related dementias. The lab employs advanced technologies, including innovative single-cell analyses and machine learning, to identify specific neuronal vulnerabilities and develop new therapeutic targets aimed at preventing or treating these conditions. Their research integrates genetic, anatomical, and pathological insights to provide a comprehensive view of AD and its impact on synaptic function.
Alzheimer's DiseaseAD-related Dementiasynapsemachine learningsingle-cell technologymulti-omicsneuron vulnerabilitytherapeutic targetsgenetic polymorphisms
Research Aims
4AIM 01Investigate selective vulnerabilities of neurons in Alzheimer's disease.
AIM 02Develop a comprehensive single-cell atlas related to Alzheimer's disease.
AIM 03Characterize the functional impacts of noncoding SNPs linked to Alzheimer's disease.
AIM 04Utilize innovative technologies to analyze synaptic injury at the single-cell level.
Skills the Lab Values
single-cell RNA sequencingmachine learningmultiplexed molecular analysisCRISPR gene editingmouse modelsimmunohistochemistrydata analysisbioinformaticssynthetic biology
Output against the department
Publications728top 3% of dept.32nd of 1,033
this lab
most publishedleast published
Citations62ktop 3% of dept.31st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.