University of Pittsburgh-Pittsburgh Campus · Microbiology & ImmunologyThe Hepatitis B Research Hub
Haitao Guo · Pittsburgh, Pennsylvania
Research Focus
Dr. Haitao Guo's lab at the University of Pittsburgh focuses on understanding chronic hepatitis B virus (HBV) infection, which affects millions of people worldwide. They investigate the role of hepatitis B e antigen (HBeAg) in the body's inability to clear HBV, which contributes to serious liver conditions like cirrhosis and liver cancer. By exploring the biological processes related to HBV persistence, their work aims to develop new treatment strategies for this public health challenge.
hepatitis B virusHBV persistenceHBeAgliver cancerimmune tolerance
Research Aims
5AIM 01Investigate the mechanisms of HBeAg-related immune suppression.
AIM 02Elucidate the biogenesis of the HBeAg protein.
AIM 03Study the epigenetic regulation of HBV cccDNA transcription.
AIM 04Analyze the interaction between HBeAg and host immune responses.
AIM 05Develop novel therapeutic strategies targeting HBV persistence.
Skills the Lab Values
cell cultureChIP-seqRNA extractionprotein assaysstatistical analysis in R
Output against the department
Publications182top 36% of dept.177th of 486
this lab
most publishedleast published
Citations8.6ktop 42% of dept.203rd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.