Columbia University in the City of New York · GeneticsTubulogenesis Research Lab
Amin S Ghabrial · New York, New York
Research Focus
Dr. Amin Ghabrial's lab studies how tubes form in living organisms, particularly in fruit flies (Drosophila). The lab focuses on understanding the genetic and molecular mechanisms that control the shape and growth of these tubes, which are crucial for the functioning of various organs. By exploring these processes, the lab aims to uncover insights that could help in treating diseases in the lungs, vascular systems, and kidneys.
Drosophilatubulogenesismolecular geneticsseamless tubestracheacell adhesionmorphogenesisembryonic developmentsignal pathwaysextracellular matrix
Research Aims
3AIM 01Dissect the signaling pathways regulating tip cell properties for tube formation.
AIM 02Investigate the mechanisms of seamless tube formation involving cytoskeletal factors and extracellular matrix.
AIM 03Explore how genetic mutations affect the regulation of multicellular tube length and diameter.
Skills the Lab Values
genetic analysismicroscopycell culturemolecular dissectionmolecular cloningbioinformaticsCRISPRmosaic analysisimmunofluorescenceprotein assays
Output against the department
Publications28bottom 4% of dept.248th of 259
this lab
most publishedleast published
Citations1.9kbottom 7% of dept.240th of 259
this lab
most citedleast cited
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