University of Michigan-Ann Arbor · GeneticsSaher Lab
Saher Sue Hammoud · Ann Arbor, Michigan
Research Focus
Dr. Saher Sue Hammoud's lab at the University of Michigan focuses on the critical process of meiosis, which is essential for the production of sperm and eggs. Their research investigates how specific proteins, particularly ZCWPW1, influence the accurate pairing and recombination of chromosomes during this process. By studying these mechanisms, the lab aims to uncover the molecular causes of chromosome mis-segregation, a leading factor in infertility and genetic disorders.
meiosischromosome segregationaneuploidyhomolog pairingrecombinationinfertilityhistone methylationgamete productionmolecular biology
Research Aims
4AIM 01Investigate the role of ZCWPW1 in homolog pairing during meiosis.
AIM 02Analyze how histone modifications influence chromosome dynamics.
AIM 03Examine the impact of disrupted homolog pairing on chromosome mis-segregation.
AIM 04Understand the genetic basis of aneuploidy in human gametes.
Skills the Lab Values
DNA double-strand break analysisgenetic manipulationbiochemical assaysimmunoprecipitationcell culturemass spectrometrymolecular cloninggenomic analysismicroscopy
Output against the department
Publications90bottom 27% of dept.189th of 259
this lab
most publishedleast published
Citations5.5kbottom 30% of dept.181st of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.