University of Alabama at Birmingham · NeuroscienceCircadian Neurobiology and Alzheimer's Unit
Erik D Roberson · Birmingham, Alabama
Research Focus
Dr. Erik D Roberson's lab at the University of Alabama at Birmingham focuses on understanding how disruptions in circadian rhythms affect brain function in relation to Alzheimer's disease. They investigate how changes in neuronal excitability, particularly in certain inhibitory neurons, may contribute to the disease's early stages. Through innovative techniques, the lab aims to uncover mechanisms linking circadian biology with cognitive impairment and develop potential therapeutic strategies.
Alzheimer's diseasecircadian rhythmsneuronal hyperexcitabilityinhibitory interneuronsgene expressionmolecular clockscognitive impairmentchemogeneticspathogenesiselectrophysiology
Research Aims
3AIM 01Investigate circadian regulation of neuronal excitability in Alzheimer's disease models.
AIM 02Evaluate gene expression in PV+ interneurons compared to excitatory neurons in the context of circadian rhythms.
AIM 03Manipulate PV+ interneuron activity to assess the effects on hyperexcitability and cognitive function in AD mice.
Skills the Lab Values
RNA sequencingbioinformaticselectrophysiologymouse modelscircuit mappingcell culturegene manipulationdata analysischemogenetic techniques
Output against the department
Publications326top 20% of dept.137th of 671
this lab
most publishedleast published
Citations33ktop 11% of dept.77th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.