Ohio State University-Main Campus · PhysiologyCardiac Rhythm and Failure Research Unit
Isabelle Deschenes · Columbus, Ohio
Research Focus
Isabelle Deschenes' lab at Ohio State University focuses on understanding the mechanisms underlying sudden cardiac death, particularly in heart failure patients. They investigate the roles of specific proteins like KChIP2 and JNK2 in heart cell communication and rhythm management. By exploring these pathways, the lab aims to discover new therapeutic strategies to prevent dangerous heart rhythms and improve patient outcomes.
sudden cardiac deathheart failureJNK2KChIP2arrhythmiasgene regulation
Research Aims
5AIM 01Investigate how KChIP2 regulates JNK2 expression.
AIM 02Explore the role of the KChIP2-JNK2 axis in arrhythmias.
AIM 03Test the effects of KChIP2 overexpression as a therapy.
AIM 04Evaluate the efficacy of JNK2 inhibition in preventing sudden cardiac death.
AIM 05Identify upstream regulators of JNK2 in heart failure.
Skills the Lab Values
cell cultureanimal modelselectrophysiologygene expression analysisWestern blotimmunoprecipitationmolecular cloningdata analysistherapeutic intervention testing
Output against the department
Publications150top 50% of dept.144th of 286
this lab
most publishedleast published
Citations3.5kbottom 28% of dept.206th of 286
this lab
most citedleast cited
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