University of California-Los Angeles · BiochemistryExtracellular Vesicle Diagnostics Lab
Hsian-Rong Tseng · Los Angeles, California
Research Focus
Dr. Hsian-Rong Tseng's lab at UCLA focuses on developing innovative ways to monitor treatment responses in pediatric patients with osteosarcoma, a type of bone cancer. The lab is working on a noninvasive test that analyzes extracellular vesicles (tiny particles released by tumors) to assess the activity of specific enzymes involved in cancer progression. This research aims to improve current diagnostic methods, offering better ways to track how well treatments are working for young patients with this aggressive disease.
extracellular vesiclesosteosarcomamatrix metalloproteinasesliquid biopsynoninvasive diagnostics
Research Aims
5AIM 01Develop a noninvasive assay for monitoring treatment responses in osteosarcoma patients.
AIM 02Utilize extracellular vesicles to profile matrix metalloproteinases activities.
AIM 03Refine and validate the OS EV MMP Activity Assay for clinical application.
AIM 04Investigate the role of proteases in tumor progression and metastasis.
AIM 05Achieve translational readiness for the developed assay for potential manufacturing.
Skills the Lab Values
click chemistryFRET assaysmolecular profilingtumor tissue analysisbiomarker development
Output against the department
Publications360top 16% of dept.64th of 402
this lab
most publishedleast published
Citations18ktop 23% of dept.93rd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.