Icahn School of Medicine at Mount Sinai · NeuroscienceThe Pituitary Nexus
Stuart C. Sealfon · New York, New York
Research Focus
Dr. Stuart C. Sealfon's lab at the Icahn School of Medicine focuses on understanding the pituitary gland's role in the endocrine system by studying the molecular changes occurring in its different cell types. Using cutting-edge single cell technologies, the lab investigates how these cells adapt during normal physiological processes and diseases like hypothyroidism. Their research aims to reveal insights into gene regulation and cell behavior, contributing to our understanding of overall health and disease dynamics.
pituitary glandendocrine systemsingle cell sequencingalternative splicinghypothyroidismmolecular biologyepigeneticscellular plasticitybioinformatics
Research Aims
3AIM 01Investigate the epigenetic mechanisms that regulate pituitary cell function across different physiological states.
AIM 02Develop new methods for analyzing gene expression and splicing in single pituitary cells during health and disease.
AIM 03Elucidate the adaptive mechanisms of pituitary cells in response to hypothyroidism using single cell techniques.
Skills the Lab Values
single cell RNA sequencingmulti-omics analysisbioinformatic software developmentlong-read sequencing techniquesmolecular cloningcell culture techniquesmouse modelsgene expression analysissplicing assays
Output against the department
Publications347top 19% of dept.128th of 671
this lab
most publishedleast published
Citations21ktop 21% of dept.138th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.