Ohio State University-Main Campus · Microbiology & ImmunologyFerroptosis and Cancer Therapy Lab
Haitao Wen · Columbus, Ohio
Research Focus
Dr. Haitao Wen's lab at Ohio State University focuses on understanding how a specific type of cell death, called ferroptosis, can be induced in cancer cells. The lab investigates how mitochondrial calcium signaling affects this process, especially in cancers that resist traditional therapies. By exploring the connections between cell death and immune response in tumors, the research aims to identify new ways to enhance cancer treatment.
ferroptosismitochondrial calciumcancer therapytumor microenvironmentimmunotherapycell deathacetylation
Research Aims
4AIM 01Investigate the role of mitochondrial calcium signaling in regulating ferroptosis in cancer cells.
AIM 02Examine how disruption of mitochondrial calcium uniporter affects antitumor immunity.
AIM 03Analyze the immune response in tumors undergoing ferroptosis.
AIM 04Evaluate therapeutic strategies targeting mitochondrial calcium signaling in cancer treatment.
Skills the Lab Values
cell culturemouse modelsRNA sequencingCRISPRflow cytometryWestern blotgenetic ablationsingle-cell RNA sequencingpharmacological inhibition
Output against the department
Publications118bottom 45% of dept.267th of 486
this lab
most publishedleast published
Citations10ktop 35% of dept.171st of 486
this lab
most citedleast cited
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