Northeastern University · PhysicsWilliams Chaperone Lab
Mark C Williams · Boston, Massachusetts
Research Focus
Dr. Mark C. Williams' lab investigates how proteins that interact with DNA, known as nucleosome chaperones, help manage gene expression by altering the accessibility of DNA. This research has implications for understanding processes like cancer and viral infections, particularly focusing on how specific modifications to proteins can affect their function. By using advanced techniques to study these interactions at a molecular level, the lab aims to uncover new therapeutic targets for diseases such as cancer and HIV.
nucleosome chaperoneschromatin modificationsHIV integrationcancer therapyDNA accessibilityhistone methylationmolecular chaperonesgene expressionoptical tweezerssingle molecule techniques
Research Aims
2AIM 01Define how FACT (FAcilitates Chromatin Transcription) functions as a chaperone for chromatin remodeling.
AIM 02Investigate how LEDGF and HDGF2 act as histone chaperones and determine their role in HIV-1 DNA integration.
Skills the Lab Values
optical tweezersDNA manipulationprotein purificationfluorescence microscopychromatin assaysnucleosome reassembly studiesbioinformaticscell cultureWestern blottingmolecular cloning
Output against the department
Publications3,121top 5% of dept.1st of 22
this lab
most publishedleast published
Citations126ktop 5% of dept.1st of 22
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.