University of California-Santa Cruz · BiochemistryTelomere Biology Lab
Carol W Greider · Santa Cruz, California
Research Focus
Dr. Carol W. Greider's lab focuses on understanding how telomere lengths are regulated at the DNA level in yeast. Telomeres are critical for chromosome stability and their lengths influence aging and cancer. The lab uses innovative techniques, such as nanopore sequencing, to investigate the specific molecular mechanisms that determine telomere lengths across different chromosomes. Insights from this research could lead to new therapeutic approaches for age-related diseases and cancer.
telomere biologytelomerasecanceryeast geneticsRNA sequencingchromosome stabilitymolecular mechanismsage-related diseasesgenomic regulation
Research Aims
5AIM 01Investigate the distinct length distributions of telomeres in yeast.
AIM 02Test the influence of subtelomeric sequences on telomere length.
AIM 03Examine the role of long non-coding RNA TERRA in telomere regulation.
AIM 04Evaluate the impact of histone deacetylases on telomere length maintenance.
AIM 05Understand how telomerase contributes to chromosome stability.
Skills the Lab Values
nanopore sequencingRNA sequencingPCRDNA manipulationcell culturegenomic data analysishistone modification techniquesyeast geneticsbioinformatics
Output against the department
Publications165bottom 47% of dept.212th of 402
this lab
most publishedleast published
Citations44ktop 6% of dept.24th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.