University of Texas Southwestern Medical Center · BiochemistryReady TissueLab
Joseph M Ready · Dallas, Texas
Research Focus
Dr. Joseph M Ready's lab studies how a specific enzyme, 15-prostaglandin dehydrogenase (15-PGDH), affects tissue healing and regeneration. They are developing small molecules that inhibit this enzyme, which could help treat various conditions involving tissue damage, such as inflammation and injury. Their research combines techniques from chemistry and biology to uncover how this enzyme functions and how its inhibition can promote recovery in the body.
tissue repair15-prostaglandin dehydrogenasePGE2drug developmentcell signalingmacrophage biologyneural repair
Research Aims
5AIM 01Define the structure of 15-PGDH with small molecule inhibitors.
AIM 02Investigate how 15-PGDH regulates cell signaling during tissue repair.
AIM 03Identify cell types expressing 15-PGDH in response to injury.
AIM 04Explore the effects of 15-PGDH inhibitors on inflammation and recovery.
AIM 05Engineer targeted knockouts to study 15-PGDH function in specific immune cells.
Skills the Lab Values
medicinal chemistrybiochemistrycell culturemouse modelssingle-cell RNA sequencingstructural biologyprotein engineeringflow cytometrycomputational modelingcytokine analysis
Output against the department
Publications226top 35% of dept.139th of 402
this lab
most publishedleast published
Citations6.4kbottom 36% of dept.256th of 402
this lab
most citedleast cited
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