University of North Carolina at Chapel Hill · PhysiologyThe Pacemaker Initiative
Michael C Bressan · Chapel Hill, North Carolina
Research Focus
Dr. Michael C. Bressan's lab at the University of North Carolina Chapel Hill focuses on understanding the cardiac pacemaker cells, which are crucial for initiating heartbeats. The lab investigates how these cells interact with their environment and support cells to maintain their function. By exploring the mechanical and chemical factors that impact pacemaker cell health, the research aims to develop new therapies for heart conditions and improve artificial pacemaker technologies.
cardiac pacemaker cellscytoarchitectureheart failureparacrine factorsextracellular matrixsinoatrial nodebiomechanicscellular interactionstherapeuticstissue engineering
Research Aims
3AIM 01Define the specific molecular pathways that integrate mechanical feedback within cardiac pacemaker cells.
AIM 02Identify the paracrine factors that maintain crosstalk between cardiac pacemaker cells and their support cells.
AIM 03Determine how interactions between cardiac pacemaker cells and supporting cells change under aging and pathological conditions.
Skills the Lab Values
cell culturemolecular biology techniquesbiomechanical testingextracellular matrix analysisimmunofluorescence microscopyRNA sequencinganimal modelsflow cytometrydata analysis in biological researchmechanical strain assessment
Output against the department
Publications43bottom 5% of dept.273rd of 286
this lab
most publishedleast published
Citations1.2kbottom 4% of dept.275th of 286
this lab
most citedleast cited
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