University of California-San Diego · BiologyOral Antiviral Drug Development Lab
Aaron F. Carlin · La Jolla, California
Research Focus
Dr. Aaron F. Carlin's lab at UC San Diego focuses on developing new oral antiviral treatments for RNA viruses, such as coronaviruses and dengue. They create and optimize lipid-based prodrugs that enhance the delivery and effectiveness of antiviral medications, aiming to improve treatment options for infections that pose significant public health risks. The research combines synthetic chemistry and pharmacokinetics to design innovative solutions for a rapidly evolving field.
RNA virusesantiviral drugslipid prodrugsoral bioavailabilitypharmacokinetics
Research Aims
5AIM 01Identify mechanisms that determine prodrug antiviral potency in vitro.
AIM 02Evaluate how lipid prodrug modifications affect tissue delivery.
AIM 03Design new lipid RVn-MP prodrugs based on in vitro and in vivo data.
AIM 04Assess the efficacy of new compounds against pathogenic RNA viruses in mice.
AIM 05Develop broad-spectrum antiviral strategies for public health concerns.
Skills the Lab Values
cell culturemass spectrometryenzyme kineticsdrug metabolism studiesstructure-activity relationship analysis
Output against the department
Publications109bottom 38% of dept.640th of 1,033
this lab
most publishedleast published
Citations9.9ktop 38% of dept.392nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.