University of California-Irvine · PhysiologyNeutrophil Immunology Lab
Steve A N Goldstein · Irvine, California
Research Focus
Dr. Steve A N Goldstein's lab at UC Irvine focuses on understanding how neutrophils, the white blood cells crucial for our immune response, contribute to lung injury during infections like COVID-19 and bacterial pneumonia. The lab investigates a specialized channel in these cells called hHv1, which plays a key role in driving inflammation. By developing inhibitors that target hHv1, the lab aims to find new treatments to prevent and mitigate acute lung injury and its severe form, ARDS.
hHv1neutrophilsacute lung injuryARDSinflammationROS productionalbumin
Research Aims
3AIM 01Investigate the structural basis for albumin's activation of hHv1 in neutrophils.
AIM 02Examine the role of hHv1 in sustaining the inflammatory response in neutrophils using specific inhibitors.
AIM 03Test the effectiveness of hHv1 inhibitors in an acute lung injury mouse model.
Skills the Lab Values
cell cultureanimal modelsimmunohistochemistryflow cytometryWestern blotpeptide synthesisbiophysical methodsmicroscopydata analysisdrug screening
Output against the department
Publications682top 2% of dept.5th of 286
this lab
most publishedleast published
Citations73ktop 1% of dept.4th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.