University of Texas Southwestern Medical Center · BiologyWang Epigenetics Lab
Yingfei Wang · Dallas, Texas
Research Focus
Dr. Yingfei Wang's lab focuses on understanding the role of epigenetics in Alzheimer’s disease, especially how certain proteins influence cognitive deficits and neuronal activity. By studying the KDM6B protein's impact in mice, the lab aims to uncover underlying mechanisms that lead to changes in synaptic function and cognitive impairment in Alzheimer's. The research could pave the way for new treatments to improve cognitive functions in patients suffering from this disease.
Alzheimer's DiseaseepigeneticsKDM6Bcognitive impairmentsynaptic plasticity
Research Aims
5AIM 01Investigate the role of KDM6B in regulating synaptic activity.
AIM 02Understand how pathological Tau influences KDM6B functions in neurons.
AIM 03Assess the impacts of KDM6B dysregulation on Alzheimer's disease progression.
AIM 04Explore the relationship between KDM6B and glutamate transporters in synaptic function.
AIM 05Identify potential therapeutic targets related to cognitive function improvement in Alzheimer’s patients.
Skills the Lab Values
mouse modelsconditional knockoutbehavioral assaysmolecular biology techniqueshistone modification analysis
Output against the department
Publications133bottom 47% of dept.545th of 1,033
this lab
most publishedleast published
Citations4.7kbottom 36% of dept.657th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.