Upstate Medical University · BiochemistryKane Lab
Patricia M Kane · Syracuse, New York
Research Focus
Patricia M Kane's lab focuses on studying V-ATPases, which are important protein pumps that help acidify cellular compartments in all eukaryotic cells. The lab investigates how these pumps are regulated and their roles in diseases like cancer, epilepsy, and Alzheimer's. By understanding the mechanisms behind V-ATPase function, the lab hopes to develop better therapeutic strategies for diseases linked to their dysfunction.
V-ATPasescellular pH homeostasiscancerepilepsyAlzheimer's disease
Research Aims
5AIM 01Investigate the regulation of V-ATPases in cellular environments.
AIM 02Characterize the structure and function of RAVE and Rabconnectin-3 complexes.
AIM 03Explore the role of V-ATPases in cancer metastasis and viral entry.
AIM 04Study the effects of V-ATPase activity loss on cellular pH homeostasis in yeast and mammalian cells.
AIM 05Assess the impact of aging on V-ATPase function and pH regulation.
Skills the Lab Values
PCRcell cultureyeast geneticsmicroscopyprotein purificationWestern blotRNA sequencingbiochemical assayslipid binding studies
Output against the department
Publications146bottom 41% of dept.238th of 402
this lab
most publishedleast published
Citations8.3kbottom 45% of dept.223rd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.