East Carolina University · Microbiology & ImmunologyThe Spirochete Dynamics Lab
Md A Motaleb · Greenville, North Carolina
Research Focus
Dr. Md A. Motaleb's lab at East Carolina University focuses on studying spirochetes, a group of bacteria responsible for serious diseases like Lyme disease and syphilis. The research aims to understand the unique flagellar proteins that enable these bacteria to move and cause disease. By investigating the molecular mechanisms of spirochete motility, the lab hopes to uncover new treatment strategies for infections caused by these pathogens.
spirochetesflagellar proteinsLyme diseaseperiplasmic flagellamolecular mechanismsbacterial motilitypathogenicitydrug designbiochemical techniques
Research Aims
3AIM 01Elucidate the role of flagellar collar proteins in stabilizing spirochetal motility.
AIM 02Discover and characterize novel flagellar proteins unique to spirochetes.
AIM 03Investigate the molecular mechanisms behind the orientation of periplasmic flagella in Borrelia burgdorferi.
Skills the Lab Values
PCRgenetic manipulationsmicrobiological techniquesbiochemical assayscryogenic electron microscopybioinformaticscell cultureprotein characterizationmolecular cloning
Output against the department
Publications67bottom 19% of dept.395th of 486
this lab
most publishedleast published
Citations2.7kbottom 17% of dept.402nd of 486
this lab
most citedleast cited
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