University of Illinois Urbana-Champaign · BiochemistryAntibody Interaction Research Lab
Nicholas C. Wu · Champaign, Illinois
Research Focus
Dr. Nicholas C. Wu's lab focuses on understanding how human antibodies recognize and bind to various antigens, which is essential for developing effective vaccines and therapies. They employ a high-throughput method to study the interactions between antibodies and influenza A virus proteins, aiming to predict antibody epitope specificity based on their amino acid sequences. This research could enhance our knowledge of the human immune system and inform better approaches to fight against pathogens.
antibody diversityepitope predictionhigh-throughput screeningimmune responseinfluenza Aantibody-antigen interactionstherapeutic developmentvaccine development
Research Aims
5AIM 01Develop a high-throughput platform for analyzing antibody-antigen interactions.
AIM 02Identify molecular features of antibodies that correlate with their epitope recognition.
AIM 03Characterize the binding specificity of antibodies to influenza A hemagglutinin.
AIM 04Predict epitopes based on antibody amino acid sequences.
AIM 05Extend findings to analyze other antigens of interest.
Skills the Lab Values
antibody sequencinghigh-throughput screeningmolecular cloningbioinformaticsprotein binding assaysdata analysis for antibody repertoirecell culture techniquesPCRimmunoassays
Output against the department
Publications259top 28% of dept.111th of 402
this lab
most publishedleast published
Citations14ktop 34% of dept.136th of 402
this lab
most citedleast cited
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