Central Michigan University · BiologyKarp Stem Cell Lab
Xantha Karp · Mount Pleasant, Michigan
Research Focus
Dr. Xantha Karp's lab at Central Michigan University is focused on understanding how stem cells maintain their ability to become different cell types while they are not actively dividing. They use the tiny worm C. elegans to study a specific protein complex that influences cell behavior, particularly during a resting state. The research aims to uncover the genetic and molecular mechanisms that help control stem cell fate, which could have important implications for medicine in the future.
stem cellsquiescenceFOXOC. elegansGATAD2cell fatenuRD complexRNA-binding proteinsdevelopmental biologygene regulation
Research Aims
3AIM 01Investigate how FOXO regulates GATAD2 activity in stem cells.
AIM 02Determine the role of GATAD2 in regulating adult cell fate.
AIM 03Identify genes affected by GATAD2 using RNA sequencing.
Skills the Lab Values
mRNA sequencingRNA interferencegenetic manipulationChIP sequencingcell cultureC. elegans handlingqPCRdata analysisprotein purificationbioinformatics
Output against the department
Publications45bottom 10% of dept.934th of 1,033
this lab
most publishedleast published
Citations1.2kbottom 7% of dept.963rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.