University of Kansas · BiologyiTTP Research and Therapeutics Unit
X. Long Zheng · Lawrence, Kansas
Research Focus
Dr. X. Long Zheng's lab at the University of Kansas Medical Center studies a rare blood disorder called immune thrombotic thrombocytopenic purpura (iTTP). They focus on understanding how certain autoantibodies disrupt normal blood function and how genetic factors might contribute to this disease. By using models and advanced techniques, the lab aims to uncover new insights that could lead to better treatments for patients suffering from iTTP and similar conditions.
iTTPautoantibodiesgenetic disordersthrombocytopeniaimmune response
Research Aims
5AIM 01Identify molecular signatures of autoantibodies in iTTP
AIM 02Investigate the role of ANKRD26/36 gene family in iTTP pathogenesis
AIM 03Develop novel strategies for therapeutic intervention in thrombotic disorders
AIM 04Utilize animal models to study disease mechanisms
AIM 05Explore immune responses in patients with iTTP
Skills the Lab Values
Molecular profilingAnimal modelsFlow cytometrySingle cell sequencingCRISPR gene editing
Output against the department
Publications302top 19% of dept.192nd of 1,033
this lab
most publishedleast published
Citations8.9ktop 43% of dept.443rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.