University of California-Davis · PharmacologyCalcium Nexus Lab
Johannes W Hell · Davis, California
Research Focus
Dr. Johannes W. Hell's lab focuses on understanding how the Alzheimer’s disease-related protein beta amyloid affects calcium channels in the brain. By studying the Cav1.2 calcium channel, the lab investigates how its dysregulation can lead to neuronal damage and impair synaptic function, which are critical in Alzheimer’s disease. This research opens up new avenues for potential pharmacological interventions to combat the early effects of Alzheimer's.
Alzheimer's diseaseCav1.2 calcium channelsbeta amyloid peptideneuronal excitabilitysynaptic transmission
Research Aims
3AIM 01Test how beta amyloid dysregulates Cav1.2 in neurons
AIM 02Investigate the impact of Cav1.2 on AMPARs in response to beta amyloid
AIM 03Explore mechanisms of synaptic plasticity affected by beta amyloid and Cav1.2 signaling
Skills the Lab Values
Calcium imagingWestern blottingLive-cell imagingMolecular cloningTransgenic mouse modelsPharmacological interventionsElectrophysiologyCell cultureBiochemical assays
Output against the department
Publications483top 11% of dept.51st of 462
this lab
most publishedleast published
Citations20ktop 18% of dept.82nd of 462
this lab
most citedleast cited
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