University of California-Los Angeles · GeneticsStem Cell Identity Research Lab
Chongyuan Luo · Los Angeles, California
Research Focus
Dr. Chongyuan Luo's lab at UCLA focuses on understanding the genetic and epigenetic mechanisms that drive cell identity changes, particularly how somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs). The research also aims to map the diverse cell types in developing human brains and their regulatory programs, which could inform our understanding of neuropsychiatric disorders. By using advanced genomic techniques, the lab seeks to uncover the complex networks that govern how cells change identity and function during development and reprogramming processes.
induced pluripotent stem cellsgene regulatory networksepigenomicscell reprogrammingbrain developmentneuropsychiatric disorderssingle-cell genomicsCRISPRDNA methylationchromatin architecture
Research Aims
5AIM 01Investigate the gene regulatory networks involved in reprogramming somatic cells to pluripotent stem cells.
AIM 02Characterize the epigenomic and chromosomal features of developing human brain cells.
AIM 03Model the dynamics of transcription factor interactions during cell fate transitions.
AIM 04Identify links between genetic variations and regulatory elements affecting cell identity.
AIM 05Explore cell-type-specific regulatory mechanisms that underlie neuropsychiatric disorders.
Skills the Lab Values
single-cell RNA sequencingCRISPR interferenceATAC-seqChIP-seqDNA methylation analysisspatial transcriptomicscell culture techniquesbioinformaticsdata modelinggenetic engineering
Output against the department
Publications109bottom 33% of dept.174th of 259
this lab
most publishedleast published
Citations11ktop 47% of dept.122nd of 259
this lab
most citedleast cited
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