University of Pennsylvania · BiologyCancer Metabolism and Therapeutics Lab
M. Celeste Simon · Philadelphia, Pennsylvania
Research Focus
Dr. M. Celeste Simon's lab focuses on understanding clear cell renal cell carcinoma (ccRCC), a common type of kidney cancer characterized by significant metabolic changes. The lab studies how these metabolic alterations impact tumor behavior and explores new therapeutic strategies to improve treatment outcomes for patients with not only ccRCC but also other related cancers. By utilizing advanced models, they aim to uncover universal metabolic pathways that could be targeted for personalized cancer therapy.
clear cell renal cell carcinomametabolic pathwaystumor microenvironmenttherapeutic strategiescancer metabolismmouse modelspatient-derived xenograftslipid metabolismsenolyticsmetabolomics
Research Aims
5AIM 01Investigate metabolic alterations in clear cell renal cell carcinoma (ccRCC).
AIM 02Develop new therapeutic approaches based on identified metabolic pathways.
AIM 03Examine the impact of ccRCC metabolism on stromal components like fibroblasts and immune cells.
AIM 04Extend findings to hepatocellular carcinoma (HCC) and soft tissue sarcoma (STS).
AIM 05Utilize advanced in vivo and in vitro models to explore treatment efficacy.
Skills the Lab Values
mouse modeling techniquesmetabolomic analysiscell culturegene expression analysisdrug efficacy assessmentorganoid culturein vivo imagingbioinformaticstumor microenvironment studiesbiochemical assays
Output against the department
Publications611top 4% of dept.45th of 1,033
this lab
most publishedleast published
Citations63ktop 3% of dept.29th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.